TCGA Research Network Publications

2018

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
Cell Reports. Volume 25 Issue 5: p1304-1317.e5 Read the full article

The chromatin accessibility landscape of primary human cancers
Science. Volume 362 Issue 6413: eaav1898 Read the full article

Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Cancer Discovery. In press. Read the full article

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
Cell Systems. Volume 7 Issue 4: p422-437.e7 Read the full article

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients
Cancer Cell. Volume 34 Issue 2: p211-224 Read the full article

Integrated Molecular Characterization of Testicular Germ Cell Tumors
Cell Rep. Volume 23 Issue 11: p3392-3406 Read the full article

The Immune Landscape of Cancer
Immunity. Volume 48 Issue 4: p812-830 Read the full article

SnapShot: TCGA-Analyzed Tumors
Cell. Volume 173 Issue 2: p530 Read the full article 

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
Cell. Volume 173 Issue 2: p400-416 Read the full article 

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples
Cell. Volume 173 Issue 2: p386-399 Read the full article 

Comprehensive Characterization of Cancer Driver Genes and Mutations
Cell. Volume 173 Issue 2: p371-385 Read the full article 

Pathogenic Germline Variants in 10,389 Adult Cancers
Cell. Volume 173 (2): p355-370 Read the full article

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Cell. Volume 173 Issue 2: p338-354 Read the full article

Oncogenic Signaling Pathways in The Cancer Genome Atlas
Cell. Volume 173 Issue 2: p321-337 Read the full article

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Cell. Volume 173 Issue 2: p305-320 Read the full article

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
Cell. Volume 173 Issue 2: p291-304 Read the full article 

The Cancer Genome Atlas: Creating Lasting Value Beyond Its Data
Cell. Volume 173 Issue 2: p283-285 Read the full article 

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas
Cancer Cell. Volume 33 Issue 4: p721-735 Read the full article 

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer
Cancer Cell. Volume 33 Issue 4: p706-720 Read the full article 

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
Cancer Cell. Volume 33 Issue 4: p690-705 Read the full article 

Genomic and Functional Approaches to Understanding Cancer Aneuploidy
Cancer Cell. Volume 33 Issue 4: p676-689 Read the full article 

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Cell Rep. Volume 23 Issue 1: p313-326 Read the full article

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Cell Rep. Volume 23 Issue 1: p297-312 Read the full article 

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.
Cell Rep. Volume 23 Issue 1: p282-296 Read the full article 

Systematic Analysis of Splice-Site-Creating Mutations in Cancer
Cell Rep. Volume 23 Issue 1: p270-281 Read the full article 

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers
Cell Rep. Volume 23 Issue 1: p255-269 Read the full article

Genomic and Molecular Landscape of DNA Damage Repair Deficiency Across The Cancer Genome Atlas
Cell Rep. Volume 23 Issue 1: p239-254 Read the full article 

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
Cell Rep. Volume 23 Issue 1: p227-238 Read the full article

Integrated Genomic Analysis of the Ubiquitin Pathway Across Cancer Types
Cell Rep. Volume 23 Issue 1: p213-226 Read the full article

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas
Cell Rep. Volume 23 Issue 1: p194-212 Read the full article

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
Cell Rep. Volume 23 Issue 1: p181-193 Read the full article

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas
Cell Rep. Volume 23 Issue 1: p172-180 Read the full article

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Cell Syst. Volume 6 Issue 3: p282-300 Read the full article

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines
Cell Syst. Volume 6 Issue 3: p271-281 Read the full article

The Integrated Genomic Landscape of Thymic Epithelial Tumors
Cancer Cell. Volume 33 Issue 2: p244-258 Read the full article

2017

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas
Cell. Volume 171 Issue 4: p950-965 Read the full article
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Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
Cell. Volume 171 Issue 3: p540-556 Read the full article
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Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma
Cancer Cell. Volume 32 Issue 2: p185-203 Read the full article

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
Cancer Cell. Volume 32 Issue 2: p204-220 Read the full article

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Cell. Volume 169 Issue 7: p1327-1341 Read the full article

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
Cell Reports. Volume 18 Issue 11: p2780-2794 Read the full article
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Integrated Molecular Characterization of Uterine Carcinosarcoma
Cancer CellVolume 31 Issue 3: p411- 423 Read the full article 
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Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma
Cancer Cell. Volume 31 Issue 2: p181-193 Read the full article
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Integrated Genomic and Molecular Characterization of Cervical Cancer
Nature. Volume 543: p378-384 Read the full article
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Integrated Genomic Characterization of Oesophageal Carcinoma
Nature. Volume 541: 169-175 Read the full article
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2016

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma
Cancer Cell Volume 29 Issue 5: p723–736 Read the full article
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Cell 164 Issue 3: p550-563 Read the full article
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2015

The Molecular Taxonomy of Primary Prostate Cancer
Cell 163 Issue 4: p1011-1025 Read the full article
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Comprehensive Molecular Characterization of Papillary Renal Cell Carcinoma
NEJM. 374: 135-145 Read the full article
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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
Cell. 163 Issue 2: p506–519 Read the full article
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Genomic Classification of Cutaneous Melanoma
Cell. 161 Issue 7: 1681-1696 Read the full article
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Comprehensive and Integrative Genomic Characterization of Diffuse Lower Grade Gliomas
NEJM. 372: 2481-2498 Read the full article
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Comprehensive Genomic Characterization of Head and Neck Squamous Cell Carcinomas
Nature. 517 (7536):576-582 Read the full article
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2014

Integrated Genomic Characterization of Papillary Thyroid Carcinoma
Cell. 159 Issue 3: 676-690 Read the full article
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The Somatic Genomic Landscape Of Chromophobe Renal Cell Carcinoma
Cancer Cell. 26 Issue 3: 319-330 Read the full article
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Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
Cell. 158 Issue 4: 929-944 Read the full article
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Comprehensive Molecular Characterization of Gastric Adenocarcinoma
Nature. 513 (7517):202-209 Read the full article
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Comprehensive molecular profiling of lung adenocarcinoma
Nature. 511 (7511):543-550 Read the full article
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Comprehensive molecular characterization of urothelial bladder carcinoma
Nature. 507 (7492):315-22. Read the full article
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2013

The Somatic Genomic Landscape of Glioblastoma
Cell. 155 (2):462-477. Read the full article
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Comprehensive molecular characterization of clear cell renal cell carcinoma.
Nature. 499 (7456):43-49. Read the full article
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Integrated genomic characterization of endometrial carcinoma.
Nature. 497 (7447):67-73. Read the full article
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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.
NEJM. 368:2059-2074.Read the full article
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2012

Comprehensive molecular portraits of human breast tumors.
Nature. 490 (7418):61-70. Read the full article
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Comprehensive genomic characterization of squamous cell lung cancers.
Nature. 489 (7417):519:525 Read the full article
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Comprehensive molecular characterization of human colon and rectal cancer.
Nature. 487 (7407):330-337. Read the full article
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2011

Integrated genomic analyses of ovarian carcinoma.
Nature. 474 (7353):609-615. Read the full article
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2010

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma.
Cancer Cell. 17 (5):510-522 Read the full article
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An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1.
Cancer Cell. 17 (1):98-110 Read the full article
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2008

Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
Nature. 455 (7216):1061-1068 Read the full article
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