AACR 2012: NCI-Sponsored Session: The Cancer Genome Atlas (TCGA) – A Rapidly Expanding Community Resource: Status Review of Data Dissemination

Sunday, April 01, 2012, 2:00 PM - 3:30 PM
Room W194, McCormick Place West, Chicago, Ill.
See the poster.

The Cancer Genome Atlas (TCGA) has a goal of describing the genomic changes in more than 20 types of human cancer over the next several years. With the support of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), a robust collaborative network of institutions and investigators has been established to accrue and process specimens and generate comprehensive, multi-dimensional genomic data, to be made rapidly available as an invaluable community resource. TCGA’s genome characterization and analysis centers and teams produce tumor genomic data at unprecedented scale and therefore must constantly innovate across the basic research spectrum, including approaches to tissue processing, DNA sequencing, and computational method development. Importantly, TCGA investigators endeavor to provide results and findings that represent not only state-of-the-art science but also foundational datasets to fundamentally advance cancer research.

The session will report TCGA progress toward the 20 tumor project goal. By the time of the AACR meeting, TCGA will have generated comprehensive genomic characterizations on more than 6,000 cases across those 20 subtypes of cancer. A major challenge has been the dissemination of TCGA data in ways to maximize their utility to multiple types of users. Speakers will discuss the plans and progress toward integrating and visualizing these complex data and innovative approaches for the generation of “bioinformatic and analysis pipelines.” In addition, data from specific tumor projects will be used to provide examples of how high-quality, multi-dimensional data sets from robust numbers of high-quality samples can be interrogated by the cancer research community to generate novel insights.

Chairperson: Kenna Shaw, National Cancer Institute, Bethesda, MD

  • TCGA – Strategy, Goals and Data Availability: Kenna Shaw, National Cancer Institute, Bethesda, Md.
  • Applying for Access to Controlled Databases: Brad Ozenberger, National Human Genome Research Institute, Bethesda, Md.
  • Resources for Users from Genome Data Analysis Centers: Greg Eley, National Cancer Institute, Bethesda, Md.
  • Integrative Analysis Examples from TCGA Tumor Projects: Raju Kucherlapti, Harvard Medical School, Boston, Mass.
  • Integrative Analysis Examples from TCGA Tumor Projects: Josh Stuart, University of California at Santa Cruz, Santa Cruz, Calif.
  • Summary and Q&A: Kenna Shaw, National Cancer Inst., Bethesda, Md. and Brad Ozenberger. National Human Genome Research Institute, Bethesda, Md.