AACR 2011: NCI-Sponsored Session: The Cancer Genome Atlas (TCGA) – A Rapidly Expanding Community Resource: Status, Review of Data Dissemination

April 03, 2011 2:00 PM - 4:00 PM
Orange County Convention Center: Room W414CD, Orlando, Florida

TCGA has a goal of identifying the genomic changes in more than 20 types of human cancer over the next several years. With the support of the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), a robust collaborative network of institutions and investigators has been established to accrue and process specimens and generate comprehensive, multi-dimensional genomic data made rapidly available to the research community. TCGA’s genome characterization and analysis centers and teams produce tumor genomic data at unprecedented scale and therefore must constantly innovate across the basic research spectrum, including approaches to tissue processing, DNA sequencing, and computational method development. Importantly, TCGA investigators endeavor to provide results and findings that represent not only state-of-the-art science but also foundational data sets to fundamentally advance cancer research.

This session will report TCGA progress toward the 20 tumor project goal. Also described will be modifications to TCGA goals and strategies made necessary by rapidly evolving technologies. A major challenge has been the dissemination of TCGA data in ways to maximize their utility to multiple types of users. Speakers will discuss the plans and progress toward integrating and visualizing these complex data and innovative approaches for the generation of "bioinformatic and analysis pipelines". In addition, data from specific tumor projects will be used to provide examples of how high-quality, multi-dimensional data sets from robust numbers of high-quality samples can be interrogated by the cancer research community.

Session Chair: Paul Spellman, Ph.D., NCI, Bethesda, Md.

Part I: Strategy and Goals of TCGA

  • TCGA 2011 – A Status Report: Brad Ozenberger, Ph.D., NHGRI, Bethesda, Md.
  • The Challenge of Tumor Accrual and Cancer Selection: Kenna Shaw, Ph.D., NCI, Bethesda, Md.
  • The Effect of Technology Development on TCGA Direction: Paul Spellman, Ph.D., NCI, Bethesda, Md.
  • Summary/ Q&A: Brad Ozenberger, Ph.D., NHGRI, Bethesda, Md.

Part II: Data Analysis and Dissemination

  • TCGA Data Portal and Genome Data Analysis Centers: Greg Eley, Ph.D., NCI, Bethesda, Md.
  • Case Studies in Data Access, Data Integration and Data Visualization
    • cBIO Cancer Genomics Portal: Nikolaus Schultz, Ph.D., Memorial Sloan-Kettering Cancer Center, New York, N.Y.
    • UCSC Genome Browser: Jing Zhu, Ph.D., University of California at Santa Cruz, Santa Cruz, Calif.
  • Summary/ Q&A: Paul Spellman, Ph.D., NCI, Bethesda, Md.