AACR 2015: Pan-Cancer Analysis of Whole Genomes

Sunday, April 19, 2015, 1:00 PM - 3:00 PM 
Terrace Ballroom II-III (400 Level), Pennsylvania Convention Center, Philadelphia, Pa.

The Pan-Cancer analysis of Whole Genomes (PCAWG) project of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) is co-ordinating analysis of more than 2,000 whole cancer genomes. Each genome is characterized through a suite of centralized algorithms, including alignment to the reference genome, standardized quality assessment and calling of all classes of somatic mutation. Scientists participating in the research projects of PCAWG are addressing a series of fundamental questions about cancer biology and evolution based on these data, a sample of which will be presented at this session. Key areas of study include: (1) Discovery of driver mutations outside of the protein-coding regions of the genome; (2) Integrating mutational signatures across tumor types and mutation categories; (3) Characterizing subclonal structures and patterns of genome evolution across cancers; (4) Investigating relationships between germline and somatic mutations; (5) Investigating biological pathways targeted by driver mutations.

  • Peter J. Campbell. Wellcome Trust Sanger Institute, Cambridge, United Kingdom
  • Lincoln Stein. Ontario Institute for Cancer Research, Toronto, Ont., Canada
  • Jan Korbel. European Molecular Biology Laboratory, Heidelberg, Germany
  • Joshua M. Stuart. University of California Santa Cruz, Santa Cruz, Calif.

For more information, please visit the AACR website