Genome Characterization Centers

The Cancer Genome Atlas (TCGA) Genome Characterization Centers (GCCs) were responsible for characterizing the genomic changes found in the tumors studied by TCGA. The GCCs used multiple platforms to provide data to the cancer research community on changes in microRNA and gene expression, single nucleotide polymorphisms and copy number changes. The GCCs also validated specific regions of interest through targeted sequencing.

The following groups, organized by area of focus, served as TCGA Genome Characterization Centers:

Copy Number Alteration (Single Nucleotide Polymorphism Characterization)

  • Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.
    Principal Investigators
    Raju Kucherlapati, Ph.D.
    Lynda Chin, M.D.
    Jonathan Seidman, Ph.D.
  • The Broad Institute, Cambridge, Mass.
    Principal Investigators:
    Matthew Meyerson, M.D., Ph.D.
    Stacey Gabriel, Ph.D.


  • Van Andel Institute, Grand Rapids, Mich.
    Johns Hopkins University, Baltimore, Md.
    Principal Investigators:
    Peter Laird, Ph.D.
    Stephen Baylin, M.D.

Gene (mRNA) Expression

  • University of North Carolina at Chapel Hill, Chapel Hill, N.C.
    Principal Investigators:
    Chuck Perou, Ph.D.
    Neil D. Hayes, M.D., M.P.H.

microRNA (miRNA) Analysis

  • British Columbia Cancer Agency, Vancouver, B.C., Canada
    Principal Investigator:
    Marco Marra, Ph.D.

Targeted Sequencing Center

  • Baylor College of Medicine, Houston, Texas
    Principal Investigators:
    David Wheeler, Ph.D.
    Richard Gibbs, Ph.D.
    Rui Chen, Ph.D.

Functional Proteomics

  • MD Anderson Cancer Center, Houston, Texas
    Principal Investigator:
    Gordon Mills, M.D., Ph.D.