Biospecimen Core Resource


Dr. Marsten Linehan
Video: The Role of Tumor Samples in TCGA (03:02)
Interactive tool that illustrates the components of The Cancer Genome Atlas.
Interactive: How It Works

The Biospecimen Core Resource (BCR) is a centralized laboratory that reviews and processes blood and tissue samples and their associated data using optimized standard operating procedures for all of The Cancer Genome Atlas (TCGA) Research Network. The BCR is located at The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, and led by principal investigator Julie Gastier-Foster, Ph.D.

The work of the BCR for TCGA included the following important functions:

  • Serving as the interface between the TCGA program and the different Tissue Source Sites collecting tumor and matched normal controls
  • Ensuring and verifying that TCGA human subjects protections and guidelines are adhered to and that all regulations are followed at each Tissue Source Site
  • Including use of language consistent with the TCGA informed consent documents
  • Examining all biospecimens to ensure they meet rigorous standards for each tumor type (including percent necrosis and percent tumor nuclei)
  • Reviewing of pathology to ensure accurate diagnosis and inclusion in TCGA
  • Collecting clinical information for each tissue and applying standardized terminology, definitions and formats that were caBIG compliant
  • Extracting and distributing DNA and RNA from tissue samples to each of the genomic characterization and sequencing centers