RESEARCHER PROFILE: Next Generation Mentoring
Dr. Hui Shen, Ph.D. is a cancer genomicist who was “born and raised in TCGA.” From the outset of her graduate education, she had the opportunity to work with multiple mentors spanning scientific fields and institutions. Her advice: “Definitely try out team science.”
The Cancer Genome Atlas: More Than a Large Collection of Data
Genomic Contributions to Breast Cancer Disparities
Dr. Tanya Keenan shares her study's findings on the genomic contributions to breast cancer disparities and advocates for inclusion in breast cancer research.
- July 2016
Longitudinal Study Charts Brain Tumor Evolution
Scientists analyzed the genomes of 114 glioblastoma tumors at the time of diagnosis and at the time of recurrence, including recurrent tumors from The Cancer Genome Atlas. The study found that the relapsed tumors likely arose years before the initial diagnosis, highlighting the complexity of glioblastoma.
- March 2016
Tumor Heterogeneity Influences the Immune System's Ability to Fight Cancer
A new study found that activation of the immune system against cancer depends on the number and variety of mutations in the tumor. The findings provide insight into immune surveillance and suggest that variation, or heterogeneity, within a tumor may be an important predictor of whether patients could benefit from immunotherapy.
- October 2015
Researchers Use TCGA Data for First Pan-Cancer Analyses of RNA-Editing
By comparing A-to-I editing sites in TCGA tumor and matched normal samples, researchers observed elevated levels of A-to-I RNA editing in most cancer types, indicating that RNA editing contributes to the diversity of the cancer transcriptome.
- September 2015
DNA Methylation Inhibitor Triggers Anti-Viral Immune Response in Cancer
DNA methyltransferase inhibitors (DNMTis) can trigger an anti-viral immune response that may sensitize cancers to already developed immunotherapies like immune checkpoint therapy.
- April 2015
Using TCGA Data to Find a Novel Target for Triple-Negative Breast Cancer