What is endometrial cancer?
Endometrial cancer develops in the cells that form the inner lining of the uterus, or the endometrium, and is one of the most common cancers of the female reproductive system among American women. In 2010, approximately 43,000 women in the United States were estimated to have been diagnosed and almost 8,000 to have died of endometrial cancer.1 This cancer occurs most commonly in women aged 60 years or older. About 69 percent of endometrial cancers are diagnosed at an early stage, and as a result about 83 percent of women will survive five years following the time of diagnosis. View additional information on endometrial cancer.
What have The Cancer Genome Atlas (TCGA) researchers learned about endometrial carcinoma?
TCGA researchers have:
- Identified four subtypes of endometrial cancer: POLE ultramutated, Microsatellite instability hypermutated, Copy number low and Copy number high
- Uncovered shared genomic features between endometrial cancer and serous ovarian cancer, the Basal-like subtype of breast cancer as well as colorectal cancer
- Characterized the marked differences between the two types of endometrial tumors (endometrioid and serous), and found that some endometrioid tumors have developed a strikingly similar pattern to serous tumors, suggesting they may benefit from a common treatment
- The serous and some of the endometrioid tumors are characterized by frequent mutations in TP53, extensive copy number alterations and few DNA methylation changes
- The rest of the endometrioid tumors are characterized by few copy number alterations, scarce mutations in TP53 and frequent mutations in PTEN and KRAS
Where can I find more information about the TCGA Research Network’s studies or studies using TCGA data?
Where can I find clinical trials to treat endometrial cancer that are supported by the National Cancer Institute (NCI)?
View a list of NCI-supported endometrial cancer clinical trials that are now accepting patients.
1American Cancer Society: Cancer Facts and Figures 2010. Atlanta, GA: American Cancer Society, 2010.