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What is uterine carcinosarcoma?
Uterine carcinosarcoma is a cancer that develops in the uterus. Carcinosarcoma signifies that, when looked at under a microscope, the tumor displays histological features of both endometrial carcinoma and sarcoma.1 Endometrial carcinoma starts in the endometrium, the inner layer of tissue lining the uterus, while sarcoma begins in the outer layer of muscle of the uterus.1
A rare cancer, uterine carcinosarcoma makes up less than five percent of all uterine cancers.2 In the U.S., about two per 100,000 women develop uterine carcinosarcoma annually.3 Roughly only 35 percent of patients survive five years after diagnosis.
Uterine carcinosarcoma is part of an effort to characterize rare tumor types. Read more about the Rare Tumor Projects.
What types of discoveries about uterine carcinosarcoma do The Cancer Genome Atlas (TCGA) researchers hope to make?
- Investigate genomic mutations and biological pathways involved in uterine carcinosarcoma
- Identify subtypes of uterine carcinosarcoma and genomic features that it shares with endometrial carcinoma and sarcoma
- Determine genomic patterns that differ between early- and advanced-stage uterine carcinosarcoma
- Characterize genomic changes associated with patient therapy response and tumor recurrence
Where can I find more information about the TCGA Research Network's studies, or studies using TCGA data?
View a list of TCGA scientific publications.
Where can I find clinical trials to treat uterine carcinosarcoma that are supported by the National Cancer Institute (NCI)?
View a list of NCI-supported uterine sarcoma clinical trials that are now accepting patients.
1 American Cancer Society. (2012) Endometrial (uterine) cancer. Retrieved from http://www.cancer.org/acs/groups/cid/documents/webcontent/003048-pdf.pdf.
2 Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, Das N, Lopes AD. (2013) Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. Cochrane Database Syst Rev. (2):CD006812. doi: 10.1002/14651858.CD006812.pub3.
3 Kernochan LE, Garcia RL. (2009) Carcinosarcomas (malignant mixed Müllerian tumor) of the uterus: advances in elucidation of biologic and clinical characteristics. J Natl Compr Canc Netw. 7(5):550-556.