|Sample Collection Complete||Data Publicly Available|
What is pancreatic cancer?
Pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer, making up more than 80 percent of cases.1 It begins in the cells of the pancreas’s ducts, which transport juices containing important digestive enzymes into the small intestine.2
Pancreatic cancer is the fourth most common cause of global cancer-related deaths, and is almost always fatal.1 In 2012, it was estimated that around 44,000 new cases of pancreatic cancer were diagnosed and more than 37,000 deaths from this disease occurred in the United States alone, affecting both men and women.3
Risk factors include having a family history of the disease itself or a history of chronic inflammation of the pancreas (pancreatitis). Other risk factors include having Lynch syndrome, diabetes, being overweight or obese, and smoking.3
Pancreatic cancer poses a particular challenge for The Cancer Genome Atlas (TCGA). All cancerous tumors are made up of a combination of normal and cancerous cells – and pancreatic cancer tumors have a relatively low percentage of cancerous cells. TCGA has strict requirements on only accepting samples of tumors with a high percentage of cancerous cells, as this allows for more accurate mutation detection. Because of the challenging nature of this disease, TCGA has relaxed its criteria regarding the percentage of cancerous cells to ensure samples received are representative of the disease. View additional information on pancreatic cancer.
What types of discoveries about pancreatic cancer do The Cancer Genome Atlas (TCGA) researchers hope to make?
- Develop novel methods and approaches to the comprehensive characterization of tumors with a low percentage of cancerous cells
- Identify unique patterns of genomic changes that divide pancreatic tumors into subgroups
- Collaborate with the International Cancer Genome Consortium (ICGC) on
- Research funded by organizations across Australia to sequence genomic DNA and RNA, and determine genome-wise methylation patterns in pancreatic cancer
- Studies funded by various Canadian organizations that aim to generate a comprehensive catalogue of genomic abnormalities found in pancreatic tumors using multiple platforms and techniques
- Projects funded by the Italian Ministry of Education, University and Research, as well as the University of Verona to analyze rare pancreatic cancers such as endocrine tumors, perform RNA expression profiling, and analyze microRNA sequence patterns
Where can I find more information about the TCGA Research Network's studies or studies using TCGA data?
View a list of TCGA scientific publications.
Where can I find clinical trials for pancreatic cancer that are supported by the National Cancer Institute (NCI)?
View a list of NCI-supported pancreatic cancer clinical trials that are now accepting patients.
1Hariharan, D., Saied, A. and Kocher, H.M. (17 Feb 2008). Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford). 10(1):58-62. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504856
2What you need to know about cancer of the pancreas. (14 July 2010). The National Cancer Institute (NCI). Booklet: NIH Publication No. 10-1560. http://www.cancer.gov/cancertopics/wyntk/pancreas
3American Cancer Society: Cancer Facts and Figures 2012. Atlanta, GA: American Cancer Society, 2012. http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/documents/document/acspc-031941.pdf