• National Cancer Institute
  • National Human Genome Research Institute

Diffuse Large B-Cell LymphomaRSS

Last Updated: May 15, 2013

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What is Diffuse Large B-cell Lymphoma?

Diffuse Large B-cell Lymphoma (DLBCL) is a lymphoid neoplasm—a cancer that affects B cells, a type of white blood cell in the immune system.

Risk of developing this disease generally increases with age and for people who have weakened immune systems due to conditions such as human immunodeficiency virus (HIV) and human T-cell leukemia type I. Infections with the Epstein-Barr virus, Hepatitis C virus, or Helicobacter pylori bacteria may also increase risk, in addition to a general family history of lymphoma or exposure to certain chemicals.1 View additional information on non-Hodgkin lymphoma.

What types of discoveries about DLBCL do The Cancer Genome Atlas (TCGA) researchers hope to make?  

  • Examine the connection between DLBCL and other health conditions such as immunological disorders, hepatitis and H. pylori infections
  • Identify molecular characteristics and genomic changes potentially associated with tumor location, progression and relapse in coordination with similar projects in this tumor type
  • Classify and describe gene expression subtypes and oncogenic pathways related to clinical features and outcomes of the disease

Where can I find more information about the TCGA Research Network's studies, or studies using TCGA data? 

View a list of TCGA scientific publications.

Where can I find clinical trials to treat DLBCL that are supported by the National Cancer Institute (NCI)?

View a list of NCI-supported DLBCL clinical trials that are now accepting patients.
 


Selected References

1What you need to know about non-hodgkin lymphoma. (12 Feb 2008). The National Cancer Institute (NCI). Booklet: NIH Publication No. 07-1567. http://cancer.gov/cancertopics/wyntk/non-hodgkin-lymphoma