Genome Characterization Centers
Genomics is a fast-moving field with novel technologies and platforms that help characterize the genome being made available to the research community on a continual basis. The Cancer Genome Atlas (TCGA) Genome Characterization Centers (GCCs) are responsible for characterizing all of the genomic changes found in the tumors studied as part of the TCGA program. The GCCs will use multiple platforms to provide data to the cancer research community on changes in miRNA and gene expression, single nucleotide polymorphisms and copy number changes. The GCCs will also be working to validate specific regions of interest through targeted sequencing.
The TCGA Genome Characterization Centers, by area of focus, are:
Copy Number Alteration (Single Nucleotide Polymorphism Characterization)
- Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.
Raju Kucherlapati, Ph.D.
Lynda Chin, M.D.
Jonathan Seidman, Ph.D.
- The Broad Institute, Cambridge, Mass.
Matthew Meyerson, M.D., Ph.D.
Stacey Gabriel, Ph.D.
- University of Southern California, Los Angeles, Calif.
Johns Hopkins University, Baltimore, Md.
Peter Laird, Ph.D.
Stephen Baylin, M.D.
Gene (mRNA) Expression
- University of North Carolina at Chapel Hill, Chapel Hill, N.C.
Chuck Perou, Ph.D.
Neil D. Hayes, M.D., M.P.H.
- British Columbia Cancer Agency, Vancouver, B.C., Canada
Marco Marra, Ph.D.
Targeted Sequencing Center
- Baylor College of Medicine, Houston, Texas
David Wheeler, Ph.D.
Richard Gibbs, Ph.D.
Rui Chen, Ph.D.