Genome Characterization Centers

Genomics is a fast-moving field with novel technologies and platforms that help characterize the genome being made available to the research community on a continual basis. The Cancer Genome Atlas (TCGA) Genome Characterization Centers (GCCs) are responsible for characterizing all of the genomic changes found in the tumors studied as part of the TCGA program. The GCCs will use multiple platforms to provide data to the cancer research community on changes in miRNA and gene expression, single nucleotide polymorphisms and copy number changes. The GCCs will also be working to validate specific regions of interest through targeted sequencing.

The TCGA Genome Characterization Centers, by area of focus, are:

Copy Number Alteration (Single Nucleotide Polymorphism Characterization)

  • Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.
    Principal Investigators
    Raju Kucherlapati, Ph.D.
    Lynda Chin, M.D.
    Jonathan Seidman, Ph.D.
  • The Broad Institute, Cambridge, Mass.
    Principal Investigators:
    Matthew Meyerson, M.D., Ph.D.
    Stacey Gabriel, Ph.D.


  • Van Andel Institute, Grand Rapids, Mich.
    Johns Hopkins University, Baltimore, Md.
    Principal Investigators:
    Peter Laird, Ph.D.
    Stephen Baylin, M.D.

Gene (mRNA) Expression

  • University of North Carolina at Chapel Hill, Chapel Hill, N.C.
    Principal Investigators:
    Chuck Perou, Ph.D.
    Neil D. Hayes, M.D., M.P.H.

miRNA Analysis

  • British Columbia Cancer Agency, Vancouver, B.C., Canada
    Principal Investigator:
    Marco Marra, Ph.D.

Targeted Sequencing Center

  • Baylor College of Medicine, Houston, Texas
    Principal Investigators:
    David Wheeler, Ph.D.
    Richard Gibbs, Ph.D.
    Rui Chen, Ph.D.

Functional Proteomics

  • MD Anderson Cancer Center, Houston, Texas
    Principal Investigator:
    Gordon Mills, M.D., Ph.D.