Genome Characterization Centers
The Cancer Genome Atlas (TCGA) Genome Characterization Centers (GCCs) were responsible for characterizing the genomic changes found in the tumors studied by TCGA. The GCCs used multiple platforms to provide data to the cancer research community on changes in microRNA and gene expression, single nucleotide polymorphisms and copy number changes. The GCCs also validated specific regions of interest through targeted sequencing.
The following groups, organized by area of focus, served as TCGA Genome Characterization Centers:
Copy Number Alteration (Single Nucleotide Polymorphism Characterization)
- Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass.
Raju Kucherlapati, Ph.D.
Lynda Chin, M.D.
Jonathan Seidman, Ph.D.
- The Broad Institute, Cambridge, Mass.
Matthew Meyerson, M.D., Ph.D.
Stacey Gabriel, Ph.D.
- Van Andel Institute, Grand Rapids, Mich.
Johns Hopkins University, Baltimore, Md.
Peter Laird, Ph.D.
Stephen Baylin, M.D.
Gene (mRNA) Expression
- University of North Carolina at Chapel Hill, Chapel Hill, N.C.
Chuck Perou, Ph.D.
Neil D. Hayes, M.D., M.P.H.
microRNA (miRNA) Analysis
- British Columbia Cancer Agency, Vancouver, B.C., Canada
Marco Marra, Ph.D.
Targeted Sequencing Center
- Baylor College of Medicine, Houston, Texas
David Wheeler, Ph.D.
Richard Gibbs, Ph.D.
Rui Chen, Ph.D.
- MD Anderson Cancer Center, Houston, Texas
Gordon Mills, M.D., Ph.D.